Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function

Mycobacterium tuberculosis represents a world-wide health risk and immunosuppression is a particular problem in M. tuberculosis infections. Although macrophages are primarily infected, dendritic cells (DCs) are important in inducing cellular immune responses against M. tuberculosis. We hypothesized that DCs represent a target for M. tuberculosis and that the observed immuno-suppression results ...

Measles virus targets DC-SIGN to enhance dendritic cell infection.

Dendritic cells (DCs) are involved in the pathogenesis of measles virus (MV) infection by inducing immune suppression and possibly spreading the virus from the respiratory tract to lymphatic tissues. It is becoming evident that DC function can be modulated by the involvement of different receptors in pathogen interaction. Therefore, we have investigated the relative contributions of different M...

DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe?

C-type lectins are calcium-dependent carbohydrate-binding proteins with a wide range of biological functions, many of which are related to immunity. DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C-type lectin expressed by dendritic cells. Dendritic cells are potent antigen-presenting cells cap...

Targeting of DC-SIGN on Human Dendritic

DC-SIGN A Guide to Some Mysteries of Dendritic Cells

other T cell stimulus, are sufficient to initiate rapid and During the last decade, dendritic cells (DCs) have come strong responses, such as T cell proliferation and lymto be appreciated as critical controllers of the immune phokine production. Potency is not simply a matter of response, especially T cell responses. Although T lymmore efficient MHC–peptide complex formation, alphocytes actuall...